Topics arising from the UK Prostate ICGC (International Cancer Genome Consortium) project.

The UK Prostate ICGC project has generated many data on a cohort of men with the prostate cancer that have the following notable features

·     Data from a range of technologies (DNA sequencing, methylation sequencing, RNA sequencing, proteomics mass-spec data)

·     Exploration of the heterogeneity of prostate 

·     Data from matched benign and disease-free prostate samples

·     High-quality linked clinical data

While these data are already being analysed, existing methods do not exploit all of these characteristics. This project will develop methods or analyses of the data to address fundamental questions on the biology and treatment of the disease. Special attention will be given to the question of integrating the proteomic data into other analyses.

Linking in to other data sets (including those of the Pan-prostate cancer group, or other cancer types) will also be possible.