RESEARCHER 5 months, for hit discovery for riboswitches
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Researcher
At the Faculty of Medicine, Department of Biomedicine in the group of Professor Ruth Brenk (http://www.uib.no/en/rg/brenk ) a full-time (100 %) position as resarcher is available for a period of 5 months years. The position is part of the project “Exploration of the TPP riboswitch as a new target for antibiotics” financed by The Research Council of Norway under the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) initiative.
About the project/work tasks:
The main focus of the project will be hit discovery and optimization for the TPP riboswitch which is a target for new antibiotics (https://www.jpiamr.eu/wp-content/uploads/2018/11/Summary_Explore.pdf ). The role of this researcher will be hit validation using an in vitro transcription/translation assay, SPR, and X-ray crystallography and structure-based ligand design. Assay development will be conducted in close collaboration with the groups of Prof. Daniel Lafontaine from the Université de Sherbrooke, Canada, and Dr. Petr Bartunek from CZ-Openscreen, Czech Republic.
The main objectives for the position are
– to validate HTS hits using an in vitro transcription/translation assay
– to validate HTS hits using SPR
– to determine the crystal structures of target-ligand complexes
– to design compounds with improved affinities and physico-chemical properties
Qualifications and personal qualities:
We can offer:
Your application must include:
It is very important that each of the scholarly works on which the committee should place special emphasis, is attached in its entirety.
The following premise forms the basis for the post as research scientist:
General information:
Further information about the position can be obtained from: Professor Ruth Brenk, e-mail: ruth.brenk@uib.no , phone: +47 55 58 60 70.
The state workforce shall reflect the diversity of Norwegian society to the greatest extent possible. People with immigrant backgrounds and people with disabilities are encouraged to apply for the position.
The University of Bergen applies the principle of public access to information when recruiting staff for academic positions.
For further information about the recruitment process, click here .
About The University of Bergen
The University of Bergen (UiB) is an internationally recognised research university with more than 14,000 students and close to 3,500 employees at six faculties. The university is located in the heart of Bergen.
Our main contribution to society is excellent basic research and education across a wide range of disciplines.
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Deadline
21st September 2022
Employer
University of Bergen
Municipality
Bergen
Scope
Fulltime (1 jobs)
Fulltime
(%)
Duration
Temporary
Place of service
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