Research Technician- Pluripotent Stem Cell and Skeletal Biology

The overall purpose of the work is to develop a human pluripotent stem cell disease model for the rare genetic condition Acrodysostosis characterised by short stature and other skeletal malformations. The post, funded by a grant from the Medical Research Council (UKRI), seeks to understand the underlying molecular pathways which are dysregulated in Acrodysostosis types 1 and 2 and ultimately find ways of correcting them. The post involves maintaining and characterising both induced pluripotent stem cells and human embryonic stem cells with and without disease relevant mutations, differentiation of these cells to skeletal lineages, and assisting with somatic cell reprogramming and CRISPR-Cas9 gene editing. The successful candidate will carry out a range of techniques including PCR, genotyping, flow cytometry, immunofluorescence, as well as histological, immunohistochemical and biochemical assays. The appointee will work with postdoctoral scientists, PhD students and technicians carrying out research using both primary human cells and cell lines in different cell biological contexts.  The post is based in the Michael Smith Building of the School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester. It will involve working with the members of the Kimber group and their collaborators in other Schools within Manchester and other Universities and Institutes.

The School/Department is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School/Department holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance. We particularly welcome applications from women for this post. All appointment will be made on merit. For further information, please visit: https://www.bmh.manchester.ac.uk/about/equality/

Our University is positive about flexible working – you can find out more here

Blended working arrangements may be considered           

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

Name: Prof Susan J Kimber

Email: sue.kimber@manchester.ac.uk

General enquiries:

Email: People.Recruitment@manchester.ac.uk

Technical support:

https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.