Probing covalent mechanisms of regulation and inhibition in mitotic kinases

PhD Opportunity: Probing Covalent Mechanisms in Mitotic Kinases

Are you passionate about cutting-edge research in molecular, cell and chemical biology and eager to make a significant impact in the field of cell division? Join our dynamic and interdisciplinary team at the University of Leeds and the University of Sheffield for a PhD project focused on probing covalent mechanisms of regulation and inhibition in mitotic kinases.

Project Overview

Mitotic kinases are essential regulators of cell division, and their precise control is crucial for maintaining genomic stability. This project aims to uncover the covalent modifications that regulate these kinases and identify novel synthetic inhibitors that can modulate their activity. By integrating high-throughput molecular discovery, structural biology, and cell biology, this research will provide insights into the understanding of kinase regulation through covalent mechanisms and pave the way for new strategies to develop inhibitors.

Why Join Us?

• Interdisciplinary Approach: Work at the intersection of chemical biology, structural biology, and cell biology. Gain expertise in advanced techniques such as mass spectrometry, protein crystallography, biochemical screening, and cell-based assays.

• Supportive Environment: Benefit from the collaborative and inclusive leadership of Richard Bayliss (Leeds), Adam Nelson (Leeds), and Helen Matthews (Sheffield), a supervisory team who are dedicated to fostering a supportive environment.

• Cutting-edge Research: Be at the forefront of scientific discovery, contributing to high-impact research that has the potential to transform our understanding of cell division and lead to the development of new biotechnological tools and therapeutics.

• Professional Development: Enhance your skills and career prospects through comprehensive mentorship, interdisciplinary training, and opportunities for national and international collaborations.

Join Us

If you are a motivated and enthusiastic student with a background in biochemistry, chemical biology, or a related field, we invite you to join us in our mission to advance scientific knowledge and make a lasting impact.