Postdoctoral Research Fellow, United Therapeutics
University of British Columbia -
Full job description
Faculty Non Bargaining
Postdoctoral Research Fellow, United Therapeutics
Yachie Laboratory School of Biomedical Engineering Faculty of Medicine (Nozomu Yachie)
Posting End Date
October 18, 2023
Note: Applications will be accepted until 11:59 PM on the day prior to the Posting End Date above.
Job End Date
Oct 15, 2024
At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.
The School of Biomedical Engineering (SBME) at the University of British Columbia (UBC) in Vancouver, BC, Canada invites applications for Postdoctoral Research Fellow positions to work on a team-based project spanning pluripotent stem cells, lung differentiation, and genomics in the de Boer (https://deboer.bme.ubc.ca/), Shakiba (https://shakiba.bme.ubc.ca/), Yachie (https://yachie-lab.org/), Zandstra (https://www.stemcellbioengineering.ca/), and Lynn (https://www.lynnlab.com/) labs.
The project is in collaboration with United Therapeutics and seeks to enable the robust, large-scale production of lung cells from patient-specific induced pluripotent stem cells (iPSCs). The project involves the use of single-cell RNA-seq, DNA barcoding, reprogramming, and lung cell differentiation.
The Faculties of Medicine and Applied Science have partnered to create the SBME, a new flagship entity at UBC, and a top strategic priority for the University and both Faculties. The SBME is a nucleus for education and training, research, and innovation in biomedical engineering, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC SBME distinguishes itself by deep training in biology, and engineering science and design, enabling SBME researchers to address the most pressing biomedical challenges of the day. Our SBME faculty conduct research that advances our fundamental understanding of human biology, and yields technologies and therapies that advance our health and wellbeing.
Individuals will report to one or more of Drs. Nika Shakiba, Dr. Carl de Boer, Dr. Nozomu Yachie, Dr. Francis Lynn, or Dr. Peter Zandstra, depending on the position, but will work collaboratively with teams across these labs regardless.
Successful candidates will have the unique opportunity to collaborate with the members of the laboratories involved in this project, integrating cutting-edge stem cell, bioinformatics and synthetic biology techniques.
The responsibilities of this position, to be determined by the Supervisor, are flexible and depend on the skills and research interests of the successful applicant. Specific tasks may include:
Human pluripotent stem cell culture including maintenance, expansion, and characterization
Derivation of induced pluripotent stem cells through reprogramming of PBMCs
Lung cell differentiation and culture
Genetic engineering of mammalian cells
Next generation sequencing and bioinformatics analysis
Single-cell RNA-seq, perturb-seq, and/or other transcriptomic analysis
Analyzing data and presenting the data in reports, publications, and presentations at local and international conferences
Helping to enhance our collaborative and interdisciplinary research environment.
Contributing to cutting-edge knowledge in the scientific community
Designing and performing experiments, analyzing results, and presenting findings
Preparing and assisting with grant applications, publications and with fulfilling regulatory requirements (animal ethics, biosafety etc.)
Training and mentoring lab personnel
Candidates must hold a PhD or MD
Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references
Candidates with strong background in either computational or experimental biology (or both) will be considered
The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral and written communication, and interpersonal skills, and a strong work ethic
Preference will be given to experimental candidates who have skills in any of the following areas: stem cell culture, lentiviral delivery, lung cell differentiation and culture, iPSC derivation, transcriptomics, bioinformatics, single-cell RNA-seq
Preference will be given to computational candidates who have skills in any of the following topics: bioinformatics, statistics, machine learning, deep learning, single cell omics, transcriptomics, and programming in R, Python, and Bash
The incumbent will receive supervision directly from one or more of Drs. Shakiba, de Boer, Yachie, Lynn, and Zandstra, depending on their exact role, but will have the opportunity to work closely with all laboratories involved in this project.
The incumbent may be required to supervise trainees involved in the research program.
Start date and stipend
The start date is as soon as possible but flexible; funding has already been received. The position is full-time for one year with the possibility of extension subject to work performance. Salary will be commensurate with qualifications and experience.
How to Apply
Candidates should provide a CV, names and contact information of 3 references, and a cover letter describing past achievements and future research interests. Note that there are several similar positions available and candidates should apply to any that interest them. Please submit your applications directly via Workday from this link.
Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents of Canada will be given priority.
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