Postdoctoral Positions to Study Core Cell Cycle Machinery in Early Development Mechanisms

  • Contract
  • Anywhere

University of Southern Denmark

At the recently established lab of Kumar Somyajit, we seek highly motivated postdoctoral candidates with prime interest in cell cycle, genome maintenance, early development mechanisms, and quantitative imaging. Experience with CRISPR-based gene editing, optical microscopy, and quantitative skills are required. Previous work in the field of genome integrity and/or experience in working on embryonic stem cells are a plus.

The Somyajit lab, based at the Functional Genomics & Metabolism (FGM) Research Unit, Department of Biochemistry and Molecular Biology , SDU, has a deep interest in studying regulatory foundations of the cell cycle, DNA replication, and genome surveillance in pathophysiology.

Application deadline: 31 July 2023.
Duration: Three years.
Starting date: approx. 1 October 2023.
Interviews will be held in August 2023.

Research Project and Role
Metabolic fluctuations (such as Redox), together with changes in DNA replication and cell cycle dynamics, balance the self-renewal and differentiation of stem cells during embryonic growth and tissue homeostasis throughout adult life. However, despite their obvious importance in cell physiology, the direct interplay among these major cellular processes still needs to be explored.

As a postdoc fellow in the Somyajit group, you will be involved in a highly interdisciplinary project uncovering regulatory foundations of core-cell cycle machinery (Cyclin-CDKs) and genome protection in the context of natural metabolic fluctuations during stem cell proliferation and their differentiation.

You will employ CRISPR-based gene editing in mammalian cell models of development (embryonic and adult stem cells) and non-transformed human cells to endogenously label and quantify – Cyclin-CDK activities and subcellular metabolic states. With these novel cell models, you will combine advanced quantitative cell biology approaches such as quantitative-image-based-cytometry- QIBC, time-lapse microscopy, super-resolution microscopy, DNA fiber techniques, RNA sequencing, with classical genetics to reveal foundational mechanistic links between metabolic fluctuations and the Cyclin-CDK activities in embryonic cell division, cell fate determination, cell fitness, and cell survival.

You will interact and collaborate closely with other researchers in the Somyajit group and with members of the different research groups within FGM and at the Department of Biochemistry and Molecular Biology. The FGM research unit currently hosts seven independent research groups focusing on various aspects of functional genomics as it pertains to the regulation of cellular differentiation, genome maintenance and organization, and metabolism. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for bioimaging, next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, and transgenic mouse work. Strategic research alliances exist with the Odense University Hospital (OUH).

Postdoc Qualifications/Requirements
We are looking for a highly motivated, dedicated, and ambitious candidate with:

  • A PhD degree in Life Science, preferably Cell Biology, Biomedicine, or Computational Biology
  • A curious mind-set with a strong interest in fundamental Cell cycle, DNA replication and Genome integrity
  • Experience with molecular cell biology, biochemistry, and optical microscopy
  • At least one first-author publication in a relevant journal in the field
  • Strong communication and collaborative skills and a desire to work in an interdisciplinary environment
  • Proficiency in spoken and written English
  • Know-how in the Genome integrity field, stem cell culture, quantitative microscopy, bioinformatics will be considered an advantage.

We offer:

  • A three-year postdoc position in a stimulating and supportive, international research environment
  • Support in developing and writing independent postdoc fellowship applications (such as EMBO long-term fellowship, Marie Skłodowska-Curie Actions-postdoc fellowship, Lundbeck Foundation-postdoc grant, Danish Cancer society- postdoc fellowship)  
  • Training in a wide range of skills including leadership, research management, communication, networking, presentations, writing of grants and manuscripts etc.
  • Mentoring and career development
  • Access to state-of-the-art equipment, facilities, and infrastructure
  • Opportunity to interact with an extensive network of national and international collaborators
  • A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
  • Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.

For further information please contact: Kumar Somyajit ([email protected] ).

Application, salary etc.
The successful applicant will be employed in accordance with the agreement between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary  and taxation .

The application must include the following:

  • A letter stating your specific interests, motivation, and qualifications for the project (max. two pages).
  • CV incl. education, work/research experience and skills relevant for the position.
  • Copy of PhD certificate. If awaiting PhD, provide a written statement from the supervisor.
  • List of publications.
  • A description of your research interests in relation to the overall aim of the project (max one page excluding references).
  • At least two signed reference letters (with referee contact details and relationship). Should your referees wish to send their letters directly to us, please have them directed to the administration (e-mail: [email protected] ) mentioning your name and title of the position in the subject line. Please note that the letters need to reach us before application deadline.

Shortlisting may be used in the assessment process.

Incomplete applications and applications received after the deadline will neither be considered nor evaluated.

To qualify you must have passed a PhD or equivalent. Applications will be assessed by an expert assessor/committee. Applicants will be informed of their assessment by the university.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Applications must be submitted electronically using the link “Apply online”. Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.

Further information for international applicants about entering and working in Denmark.

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