Postdoctoral Fellow 4 – Neurosurg – Rostomily
Houston Methodist Academic Institute
At Houston Methodist, the Postdoctoral Fellow position is responsible for performing basic research duties under the supervision/direction of a Physician and/or Principal Investigator (PI). This position may work in a laboratory setting or may consist of computer work that supports the department’s research mission.The Rostomily Lab at Houston Methodist Research Institute is seeking a postdoctoral fellow with an interest in pursuing a novel aspect of the emerging field of “Cancer Neuroscience”. The NINDS and NCI funded studies leverage glioblastoma (GBM) stem cell (GSC) electrophysiology as a therapeutic target. In collaboration with investigators at HMRI (Phil Horner), Baylor College of Medicine (Francois St. Pierre and Ben Arenkiel) and TAMU IBT (Cliff Stephan), we seek to determine how modulation of resting GSC voltage membrane potential (Vmem) effects malignant properties of GSCs including proliferation, differentiation, and response to standard therapies like TMZ. One project utilizes patterned optogenetic modulation of Vmem in GSCs in vitro and in vivo while a second project seeks to develop a multiplexed platform for high-throughput drug screening using genetically encoded voltage indicators (GEVIs) and live cell fluorescent reporters of cell cycle (FUCCI) and G0-G1 transition (p27). The unifying principle behind these projects is that GSC hyperpolarization can reprogram GSCs to a less malignant non-stem cell phenotype with increased treatment responsiveness. The studies employ multiple techniques including whole cell patch clamp, high-throughput patch clamp, voltage, and cell cycle reporter imaging, GSC phenotyping, xenograft glioma models, in vitro and in vivo optogenetic manipulation of GSCs, and high throughput ion channel drug screening. Positions are open for both projects immediately. Experience in neural cell culture, electrophysiology, neural or cancer stem cell culture and phenotyping, CNS mouse models of neural disease or cancer, optogenetics and/or fluorescent readouts and high throughput drug screens is essential. The positions are supported from the following grants:“Patterned optogenetic neuromodulation to reprogram glioma stem cells”. 1R21NS127229“A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state”. 1R61CA278458PEOPLE ESSENTIAL FUNCTIONS
SERVICE ESSENTIAL FUNCTIONS
QUALITY/SAFETY ESSENTIAL FUNCTIONS
FINANCE ESSENTIAL FUNCTIONS
GROWTH/INNOVATION ESSENTIAL FUNCTIONS
This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.
EDUCATIONWORK EXPERIENCE
Postdoctoral Fellow 1 – One year of Postdoc experience
Postdoctoral Fellow 2 – Two years’ Postdoc experience
Postdoctoral Fellow 3 – Three years’ Postdoc experience
Postdoctoral Fellow 4 – Four years’ Postdoc experienceLICENSES AND CERTIFICATIONS – REQUIRED
KNOWLEDGE, SKILLS, AND ABILITIES
SUPPLEMENTAL REQUIREMENTSWORK ATTIRE
ON-CALL*
*Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below.
TRAVEL**
**Travel specifications may vary by department**
Company Profile:Houston Methodist Academic Institute oversees the Education Institute and Research Institute, including 772 faculty and 56,250 learners. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports more than 1,000 trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports more than 1,387 clinical research protocols and $70.3 million in extramurally funded translational research programs.Houston Methodist is an equal opportunity employer inclusive of women, minorities, disabled persons and veterans.Equal Employment OpportunityHouston Methodist is an Equal Opportunity Employer.Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.
Houston, TX
Sat, 15 Jun 2024 07:38:34 GMT
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