Postdoctoral Fellow 4 – Neurosurg – Rostomily
Houston Methodist Academic Institute
At Houston Methodist, the Postdoctoral Fellow position is responsible for performing basic research duties under the supervision/direction of a Physician and/or Principal Investigator (PI). This position may work in a laboratory setting or may consist of computer work that supports the department’s research mission.The Rostomily-Mikheev Lab at the Houston Methodist Research Institute is seeking a post-doctoral fellow to establish the role of novel dual NR4A1 and NR4A2 nuclear orphan receptor inhibitors in glioblastoma (GBM). NR4A1/2 drives crosstalk between immune suppression and EMT and their inhibition is hypothesized to overcome resistance to immune checkpoint blockade and standard TMZ/XRT therapies by concurrently reprogramming the mesenchymal and immune suppressive tumor microenvironment. The candidate will be involved in quantifying the effects of NR4A1/2 inhibition on reprogramming the GBM TME in syngeneic models using multiple approaches including scRNAseq, spatial IHC and transcriptomics and bioinformatic modeling to measure TME changes. The role of NR4A1/2 regulated targets, TWIST1 and PD-L1, in TME modulation and treatment responses will be defined through gain and loss of function studies. These studies are expected to support clinical development of the NR4A1/2 drugs as standalone or adjuvant therapies to potentiate current standard of care and/or immune checkpoint treatment in GBM.The position is open and available for starting immediately. The project is funded through a recently awarded R01 “Pharmacologic targeting of NR4A1 and NR4A2 to activate glioblastoma treatment response” (1R01NS129720) in collaboration with Dr Steven Safe at Texas A&M who developed the drugs and has expertise in NR4A1/2 in cancer. Competitive candidates are expected to have experience in cancer molecular biology, cancer mouse models, cancer pharmacology and/or immuno-oncology and a sincere interest in translational research for the benefit of cancer patients.PEOPLE ESSENTIAL FUNCTIONS
SERVICE ESSENTIAL FUNCTIONS
QUALITY/SAFETY ESSENTIAL FUNCTIONS
FINANCE ESSENTIAL FUNCTIONS
GROWTH/INNOVATION ESSENTIAL FUNCTIONS
This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.EDUCATION
WORK EXPERIENCE
Postdoctoral Fellow 1 – One year of Postdoc experience
Postdoctoral Fellow 2 – Two years’ Postdoc experience
Postdoctoral Fellow 3 – Three years’ Postdoc experience
Postdoctoral Fellow 4 – Four years’ Postdoc experienceLICENSES AND CERTIFICATIONS – REQUIRED
KNOWLEDGE, SKILLS, AND ABILITIES
SUPPLEMENTAL REQUIREMENTSWORK ATTIRE
ON-CALL*
*Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below.
TRAVEL**
**Travel specifications may vary by department**
Company Profile:Houston Methodist Academic Institute oversees the Education Institute and Research Institute, including 772 faculty and 56,250 learners. The Academic Institute aligns our research and education initiatives in service to the clinical mission, providing solutions that answer the call for new technologies and skills our clinicians need for patient care. Houston Methodist Education Institute coordinates our primary academic affiliation with Weill Cornell Medicine and other joint programs, including the Engineering Medicine Program at Texas A&M University Intercollegiate School of Engineering Medicine. The Education Institute also oversees continuing medical education and graduate medical education, and supports more than 1,000 trainees in residence for medical, nursing, allied health and research education programs. Houston Methodist Research Institute supports research programs and infrastructure that enable faculty across the system to bring new scientific discoveries to patients as rapidly as possible through the full cycle of a cure from conceptual bench research, to prototyping and development, to clinical trials and FDA approval. The Research Institute supports more than 1,387 clinical research protocols and $70.3 million in extramurally funded translational research programs.Houston Methodist is an equal opportunity employer inclusive of women, minorities, disabled persons and veterans.Equal Employment OpportunityHouston Methodist is an Equal Opportunity Employer.Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.
Houston, TX
Sat, 15 Jun 2024 07:31:12 GMT
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