Postdoctoral Fellow

Medical College of Wisconsin

Position Description:

Every day, in ways both big and small, the Medical College of Wisconsin (MCW) is impacting lives for the better. MCW … changemaking for a healthier Wisconsin. In the role of  Postdoctoral Fellow you will beworking in Cell Biology, Neurobiology and Anatomy.  

Purpose

A Postdoctoral Fellow position is available in the Department of Cell Biology, Neurobiology, and Anatomy in the lab of Dr. Brian Lin to study the therapeutic efficacy and underlying mechanisms of cation channel blockers to treat heart disease, with a focus on dystrophic cardiomyopathy in Duchenne muscular dystrophy. We use a variety of mouse models in vivo and human stem cell models in vitro to study treatments for DMD. We apply biophysical measurements of individual cardiac muscle cell contraction and ion transients to determine underlying mechanisms of disease and identify new therapies.

We welcome motivated, and organized candidates who can work independently in a basic research laboratory setting. Ideal candidates will have a research backgrounds in any combination of the following: cardiac physiology, animal modeling, stem cell engineering, molecular biology techniques (e.g. qPCR and Western blotting), transcriptomics/proteomics or single cardiomyocyte biophysics. Our lab ethos is that anyone can learn, and we will provide appropriate training to further develop the skillsets of trainees.

Primary Functions                 

  • Measure contractile and ion transient kinetics of individual cardiac cells 
  • Design, organize, and run a preclinical trials in mouse models of heart disease, and detailed tracking of all animals enrolled 

  • Design and run preclinical trials-on-a-chip in human stem cell derived models of heart disease 
  • Detect gene expression and protein expression using traditional biomolecular methods (qPCR and Western blotting) 
  • Determine signaling pathways using gene set enrichment or Ingenuity pathway analysis of transcriptomic datasets 
  • Proficient in scientific data management and analysis platforms (e.g. GraphPad Prism) 

  • Participate in collaborations and communication with the principal investigators and fellow scientists 
  • Participate in regular one-on-one and lab meetings with principal investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures 
  • Participate in departmental meetings and national meetings by presenting research progress

Knowledge – Skills – Abilities

Applicants should have extensive experience with common lab techniques such as qPCR, Western blotting, and cell culture. Experience with animal handling, cell and molecular biophysics are strongly urged to apply.

Applicants must be highly self-motivated and possess the ability to think and work independently. Strong scientific communication skills, open to learning new science, and scientific integrity are required.

Preferred Schedule:

M-F 8-5 pm

Position Requirements:

Minimum Required Education:               PhD or MD (or equivalent)

Minimum Required Experience:             None

Preferred Education:                             Biology

Preferred Experience:                            Prior laboratory experience strongly preferred in the areas of Molecular

                                                            Biology, Tissue Culture, Animal Handling

Field:                                                    Biochemistry, Cell Biology, Pharmacology, Structural Biology

Why MCW?

  • Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
  • 403B Retirement Package
  • Competitive Vacation and Paid Holidays offered
  • Tuition Reimbursement
  • Paid Parental Leave
  • Pet Insurance
  • On campus Fitness Facility, offering onsite classes.
  • Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc. 

For a full list of positions see: www.mcw.edu/careers  

For a brief overview of our benefits see: https://www.mcw.edu/departments/human-resources/benefits

Eastern Wisconsin is a vibrant, diverse metropolitan area.  MCW is intent on attracting, developing, and retaining a diverse workforce and faculty body that reflects the community we serve. We value diversity of backgrounds, experience, thought, and perspectives to advance excellence in science and medicine.  MCW is a welcoming campus community with a strong culture of collaboration, partnership, and engagement with our surrounding community. For more information, please visit our institutional website at https://www.mcw.edu/departments/office-of-diversity-and-inclusion


MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination


The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual’s race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.


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