Postdoctoral Associate- Viral Pathogenesis

Job title:

Postdoctoral Associate- Viral Pathogenesis

Company

Stony Brook Medicine

Job description

Required Qualifications: (As evidenced by an attached resume)
Doctoral Degree (or foreign equivalent) in Biology, Microbiology, Virology, or Biochemistry in hand by the time of hire. Experience with viral infections and analysis of cellular responses to viral infection. Understanding of experimental procedures used to study viral replication, spread and the induction of innate and adaptive immune responses. Understanding of viral analysis using molecular approaches, single cell analysis and systemic viral spread directed neurovirulence.Preferred Qualifications:
PhD or Postdoc experience in Flavivirus research. Experience in BSL3 with neuropathogenic viruses and ABSL3 murine models. Two (2)- Five (5) years of molecular biology experience with viral infected cells/mice and the use of viral reverse genetics approaches. Analysis of murine CNS and immune responses using single cell RNA sequencing, qRT-PCR analysis of cellular and viral transcripts, in situ hybridization, and flow cytometry. Experience with tissue and CNS dissociation and cell isolation.Brief Description of Duties:
The Postdoctoral Associate will be a team of scientists, graduate students and technicians in the lab of in the . The incumbent will perform research on Powassan virus in cells and using an age-dependent murine disease model to analyze neuropathogenic mechanisms. The Associate will ensure that all experiments are appropriately conducted following the policies and procedures of Stony Brook University.

• Perform POWV experiments and analyze data following viral infection of primary cells and cell lines in BSL2/BSL3, and following murine infection in ABSL3 settings.
• Analyze viral responses of infected and uninfected CNS cells and assess and quantitate viral and cellular proteins and RNA transcriptional responses using immunohistochemistry, Western blot, scRNAseq, qRT-PCR and ISH.
• Evaluate potential therapeutics for preventing POWV entry into the CNS and neurovirulence in a murine model.
• Conduct experiments using recombinant approaches to generate and evaluate recombinant POWVs modified by reverse genetics as potential vaccines, and to define interactions with cell proteins, the induction of cytokines, and the regulation of CNS protective immune responses.
• Work with and direct experimental studies, guide, direct and analyze studies of technicians and graduate students.
• Document data generated in studies, collect data, analyze data and prepare manuscripts and figures for publication in scientific journals and national and international scientific meetings and assist with grant reports, grant proposal writing and compliance reports.
• General Lab maintenance and ordering of supplies needed for studies.
• Other duties as assigned.

Special Notes:
The Research Foundation of SUNY is a private educational corporation. Employment is subject to the Research Foundation policies and procedures, sponsor guidelines and the availability of funding. FLSA Exempt position, not eligible for the overtime provisions of the FLSA. Minimum salary threshold must be met to maintain FLSA exemption.Visit to learn more about our postdoctoral community.Resume/CV and cover letter should be included with the online application.Stony Brook University is committed to excellence in diversity and the creation of an inclusive learning, and working environment. All qualified applicants will receive consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, familial status, sexual orientation, gender identity or expression, age, disability, genetic information, veteran status and all other protected classes under federal or state laws.If you need a disability-related accommodation, please call the university Office of Equity and Access (OEA) at (631) 632-6280 or visit .In accordance with the Title II Crime Awareness and Security Act a copy of our crime statistics can be viewed .Visit our page to learn about the total rewards we offer.The starting salary range (or hiring range) to be offered for this position is noted below, it represents SBU’s good faith and reasonable estimate of the range of possible compensation at the time of posting.

Expected salary

Location

Stony Brook, NY

Job date

Sun, 14 Jul 2024 07:44:45 GMT

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