POSTDOCTORAL ASSOCIATE

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

POSTDOCTORAL POSITION IN NEUROINFLAMMATION AND COGNTIVE OUTCOMES – DUKE UNIVERSITY

Department of Anesthesiology

The Terrando lab (http://anesthesiology.duke.edu/?page_id=838077) is interested in the mechanisms underlying postoperative neurocognitive disorders and novel strategies to modulate neuroinflammation and innate immunity.

Current NIH funded projects focus on:

• neuro-immune interactions after surgery, with a focus on the role of the blood-brain barrier opening during neurodegeneration

• cellular senescence and aging in postoperative delirium, including neuroinflammation modeling in organ-on-chip technologies

• neuromodulation and therapeutics to treat postoperative neurocognitive disorders

We seek a highly-motivated individual to study how peripheral surgery impacts these processes. Key guiding questions include (i) what are the effects of surgery on the neurovascular unit and blood-brain barrier? (ii) how inflammation affects glial function and activity in animal models and microphysiological systems? (iii) does microglia modulation prevent postoperative delirium or delay disease progression in susceptible models of neurodegeneration? For recent representative work of our lab please see: https://www.nature.com/articles/s41590-020-00812-1 and https://www.bjanaesthesia.org/article/S0007-0912(22)00264-1/fulltext

A PhD degree is required with training in neuroscience, immunology, biochemistry, molecular biology, pharmacology, and/or a related field. Experience with mouse models, biochemistry/molecular biology, and behavioral assays is required. Familiarity with sequencing methods and/or cellular (hiPSCs and cell lines) is welcomed. The candidate will work in a strong interdisciplinary and collaborative environment at Duke University and Duke Medical Center.

The Terrando lab cares about the well-being of all members of our team. Everyone is treated equally, irrespective of race, ethnicity, gender, religion, citizenship, disabilities, political views, family status, and sexual orientation. If you are interested in joining our collaborative and supportive scientific community, please contact us!

Niccolo Terrando, Ph.D.

Associate Professor of Anesthesiology, Cell Biology and Immunology niccolo.terrando@duke.edu

Duke University is an equal opportunity / affirmative action employer.

Minimum Qualifications

Education

See job description for education requirements.

Experience

See job description for requirements.

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