PhD student in Pharmacometrics

Published: 2022-10-12

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

The Department of Pharmacy at Uppsala University is an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-class education and extensive collaborations we constitute a driving force in the development of our academic field.

In this inspiring environment our rich diversity of research groups develop and conduct work of great scientific importance. Among our core competences are pharmacokinetics-pharmacodynamics, in vitro ADME models, advanced in vivo methods and societal aspects from optimizing the use of drugs in individuals to societal pharmaceutical policies. For more information go to www.farmaci.uu.se

Our scientific focus areas in selection:

Biological drugs •Drug Delivery • Molecular Pharmaceutics • Pharmacokinetics & Pharmacodynamics • Pharmacometrics • Pharmacodepidemiology • Social Pharmacy

Read more about our benefits and what it is like to work at Uppsala University

Duties
A doctoral position with a focus on developing methods for the design and analysis of clinical studies with the aim of providing a basis for regulatory decision-making is available in the pharmacometrics group at the Department of Pharmacy.

Many decisions in clinical drug development are supported by pharmacometric analyzes of pharmacokinetic and pharmacodynamic data. These analyzes are based on longitudinal data from one or more studies in healthy volunteers and/or patients. The pharmacometric analysis on clinical data improves internal decision-making of pharmaceutical companies and makes the drug development process more efficient. Although these methods are also used by regulatory authorities, this takes place to a limited extent when it comes to whether or not a drug is to be approved. Authorities are responsible for the approval of both original medicines and generic drug products. Within this project, we intend to improve the possibilities that pharmacometric methods can form the basis for approval decisions of regulatory agencies. We have existing collaborations with authorities in both Europe and the USA that aim to develop such methodology. In this project, such collaborations will take place, as well as studies that are initiated and carried out within the research group.

The holder of a doctoral position must primarily focus on his/her research studies. Other tasks at the department, for example administration and teaching can be included to a level not exceeding 20% of the working time.

Requirements
Suitable background for the PhD position is a bachelor’s degree in pharmacy, medicine, or engineering with a focus on pharmaceuticals (at least 240 credits). Alternatively, an applicant has Master’s education in pharmaceutical modelling, statistics and applied mathematics or pharmaceutical development.

We place great emphasis on personal suitability and motivation on the research in pharmacometrics. Experience with statistical programing such as NONMEM and R is essential. Research experience in pharmacometric methodology development, regulatory science, software development is valuable. The applicant must be able to express themselves well, both orally and in writing, in English. Furthermore, the applicant must have good collaborative skill and presentation skill and conduct a scientific project in a structured and methodical manner in the context of international collaboration.

Further information about the research-level education, eligibility requirements, and admission regulations can be found at Research Training Programmes . Applications will be ranked by the supervisors in consultation with the Department Research-level Education group. The committee for Research-level Education at the Disciplinary Domain of Medicine and Pharmacy will admit the PhD student.

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University’s rules and guidelines .

Application
The application should include (i) a motivation letter with a brief description of the candidate and research interests as well as experiences in relation to the requirements and qualifications listed above, and the topic pharmacometrics, (ii) the candidate’s CV, (iii) copies of diplomas and certificates, (iv) one recommendation letter, and (v) thesis as well as other relevant documents that the applicant wish to refer to.

About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %. Starting date 1 December 2022 or as agreed. Placement: Uppsala.

For further information about the position, please contact: Professor Mats Karlsson, [email protected]

Please submit your application by 28 October 2022, UFV-PA 2022/3618.

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Submit your application through Uppsala University’s recruitment system.

Placement:
Department of Pharmacy

Type of employment:
Full time
, Temporary position longer than 6 months

Pay: Fixed salary

Number of positions: 1

Working hours: 100 %

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative:
ST/TCO
[email protected]
Seko Universitetsklubben
[email protected]
Saco-rådet
[email protected]

Number of reference: 2022/3618

Last application date: 2022-10-28

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