PhD student in Laboratory of Molecular Pathogenetics

Institute of Biotechnology of the Czech Academy of Sciences
Ph.D. student will work on innovative projects regarding different ways in which epigenetic signals and transcription factor networks govern self-renewal, cell specification, differentiation, and reprogramming – a crucial step for advances in cell-based therapy and perspectives for medicine.
Using mouse models, we aim to investigate how disruption of transcription networks affect epigenetic landscapes and downstream targets during embryonic development. We will use Cre/loxP and Crispr/Cas9 technologies, global gene expression profiling (RNA sequencing), single cell RNA sequencing, CUT&Tag chromatin profiling, FACS, confocal microscopy, immunohistochemistry, and in situ hybridization to evaluate embryonic phenotypes.
Who are we:
Using genetically modified mouse models and gene expression profiling, we identify molecular targets for the development of preventive and diagnostic strategies.
Our focus:
- transcriptional regulation in neurosensory development and maintenance in the inner ear model
- the molecular mechanisms involved in pathologies associated with diabetes mellitus
- the molecular causes of abnormal embryonic development
More information can be acquired from our websites:
https://www.ibt.cas.cz/en/research/laboratory-of-molecular-pathogenetics/
https://www.biocev.eu/en/research/development-of-diagnostic-and-therapeutic-procedures.7/molecular-pathogenetics.13
Related publications:
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