Offer Description
Development of cancer requires pre-cancerous cells to evolve ways to circumvent the limited replicative lifespan of human somatic cells. In up to 80–90% of cancers this is mediated by overexpression of the telomerase multiprotein-RNA complex, which elongates chromosomal ends using an RNA template.
Although targeting the telomerase pathway is a promising strategy for cancer treatment, to date, no pharmacological options for disrupting oncogenic telomerase activity have been approved for regulatory use, despite significant advancements in this field. However, we have recently demonstrated that deficiency specific DNA damage proteins leads to defects in RNA quality control, which affects the stability of the telomerase RNA-component, conferring telomere dysfunction and cellular growth arrest. The key knowledge need is to translate this finding into a therapeutic application.
For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/259850/phd-research-fellow-in-dna-repair-and-telomere-stability-in-cancer
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