PhD Fellowship in cancer treatment-mediated colitis and the intestinal microbiome

  • Contract
  • FullTime

University of Stavanger


3 Jul 2023
Job Information

Organisation/Company
University of Stavanger
Department
Department of Chemistry, Bioscience and Environmental Technology
Research Field
Medical sciences » Medicine
Biological sciences » Biology
Biological sciences » Other
Engineering » Biomaterial engineering
Researcher Profile
First Stage Researcher (R1)
Country
Norway
Application Deadline
6 Aug 2023 – 23:59 (Europe/Oslo)
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
37,5
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description
Job description

The University of Stavanger invites applicants for a PhD Fellowship in cancer treatment-mediated colitis and the intestinal microbiome at the Faculty of Science and Technology, Department of Chemistry, Bioscience and Environmental Engineering. The position is vacant from September 2023.

This is a trainee position that will give promising researchers an opportunity for academic development through a PhD education leading to a doctoral degree.

The hired candidate will be admitted to the PhD program in Science and Technology. The education includes relevant courses amounting to about six months of study, a dissertation based on independent research, participation in national and international research environments, relevant academic communication, a trial lecture and public defence. Read more about the PhD education at UiS on our website.

The appointment is for three years with research duties exclusively.

The position is funded by The Research Council of Norway.

The PhD Fellow will be affiliated with the following project: “The role of Blastocystis in inflammatory bowel disease”. This is a large interdisciplinary project with collaborators at the Stavanger University hospital, the Staten Serum Institute (SSI) in Copenhagen, Denmark, and the Institute of Parasitology in České Budějovice, Czech Republic. See here  for more information.

The PhD student will be part of a team including one Postdoctoral Fellow, four PhD students and a study nurse.

The project will be carried out at the University of Stavanger (UiS) and Stavanger University hospital under the guidance of Professor Mark van der Giezen (UiS) and Professor II Emiel Janssen (SUS). 

About the project

In the clinic, microbial eukaryotes are usually treated as parasites. However, recent data suggest a possible beneficial and/or commensal role for intestinal eukaryotes such as Blastocystis. Given the widespread distribution of Blastocystis in the general population and our preliminary data, we hypothesise that this intestinal microbe plays a beneficial role in human intestinal health. The current literature on Inflammatory Bowel Disease (IBD) and the gut microbiome has mainly focused on the bacterial microbiome while ignoring microbial eukaryotes. Therefore, it remains unknown whether gut microbial eukaryotes such as Blastocystis are associated with clinical outcomes such as disease activity, gut inflammation, treatment response, or quality of life. In the current project we will focus on patients with immune-mediated colitis (IMC) after cancer immunotherapy which is clinically, endoscopically, and histopathologically similar to IBD. Although the advent of immune checkpoint inhibitors has enabled a new, higher standard of care in various cancers, this treatment sometimes leads to a systemic loss of tolerance resulting in immune-related adverse effects. Of these, colitis is one of the most common and severe. Therefore, we need to understand if the presence or absence of Blastocystis in cancer patients receiving immunotherapy affects their risk for developing immunotherapy mediated colitis (IMC). This crucial information will inform future clinical practice and prevent unnecessary patient suffering. 

See here  for more information about Helse Stavanger HF, Stavanger University hospital.

Qualification requirements

We are looking for applicants with a strong academic background who have completed a five-year master degree (3+2) within biomedicine or other relevant discipline, preferably acquired recently; or who possess corresponding qualifications that could provide a basis for successfully completing a doctorate.

    To be eligible for admission to the doctoral programmes at the University of Stavanger both the grade for your master’s thesis and the weighted average grade of your master’s degree must individually be equivalent to or better than a B grade. If you finish your education (masters degree) in the fall 2023, you are also welcome to apply.

    Applicants with an education from an institution with a different grade scale than A-F, and/or with other types of credits than sp/ECTS, must attach a confirmed conversion scale that shows how the grades can be compared with the Norwegian A-F scale and a Diploma Supplement or similar that explains the scope of the subjects that are included in the education. You can use these conversion scales  to calculate your points for admission.

    It will be an advantage to have experience with:

    • molecular biology techniques like next-generation sequencing, preferably Oxford Nanopore
    • oncology patient related studies
    • microbiome analyses, bioinformatics (for example R/perl/python/ruby/java)
    • relevant publications of own research 

    Emphasis is also placed on your:

    • motivation and potential for research within the field
    • professional and personal skills for completing the doctoral degree within the timeframe
    • ability to work independently and in a team, be innovative and creative
    • ability to work structured and handle a heavy workload
    • having a good command of both oral and written English

    You should attach cover letter showing your motivation and interest in the project, and the relevance of your background and experience. 

    Requirements for competence in English

    A good proficiency in English is required for anyone attending the PhD program. International applicants must document this with a valid test certificate from one of the following tests:

    • TOEFL – Test of English as a Foreign Language, Internet-Based Test (IBT). Minimum result: 90
    • IELTS – International English Language Testing Service. Minimum result: 6.5
    • Certificate in Advanced English (CAE) or Certificate of Proficiency in English (CPE) from the University of Cambridge
    • PTE Academic – Pearson Test of English Academic. Minimum result: 62

    The following applicants are exempt from the above requirements:

    • Applicants with one year of completed university studies in Australia, Canada, Ireland, New Zealand, United Kingdom, USA
    • Applicants with an International Baccalaureate (IB) diploma
    • Applicants with a completed bachelor’s and / or master’s degrees taught in English in a EU/EEA country
    • Applicants who are exempt based on NOKUT’s GSU list

    We offer

    • a PhD education in a large, exciting and societally important organisation
    • an ambitious work community which is developing rapidly. We strive to include employees at all levels in strategic decisions and promote an informal atmosphere with a flat organisational structure.
    • salary in accordance with the State Salary Scale, l.pl 17.515, code 1017, NOK 532 200 gross per year with salary development according to seniority in the position. A higher salary may be considere in special cases. From the salary, 2% is deducted as a contribution to the Norwegian Public Service Pension Fund.
    • automatic membership in the Norwegian Public Service Pension Fund , which provides favourable insurance- and retirement benefits
    • favourable membership terms at a gym and at the SIS sports club  at campus
    • employment with an Inclusive Workplace organisation which is committed to reducing sick leave, increasing the proportion of employees with reduced working capacity, and increasing the number of professionally active seniors
    • “Hjem-jobb-hjem”  discounted public transport to and from work
    • as an employee in Norway, you will have access to an optimal health service, as well as good pensions, generous maternity/paternity leave, and a competitive salary. Nursery places are guaranteed and reasonably priced
    • relocation programme
    • language courses : On this page you can see which language courses you may be entitled to (look up “language courses” under employment conditions)

    Diversity

    University of Stavanger values independence, involvement and innovation. Diversity is respected and considered a resource in our work and learning environment. Universal design characterises physical and digital learning environments, and we strive to provide reasonable adjustments for employees with disabilities.

    You are encouraged to apply regardless of gender, disability or cultural background.

    Contact information

    More information on the position (and project description) can be obtained from Professor Mark van der Giezen, tel.: +47 51 83 44 93, e-mail: [email protected]  or Professor II Emiel Janssen, tel.: +47 95 89 09 63, e-mail: [email protected]

    Information about the appointment procedure can be obtained from HR advisor Rosa Andrade, tel: +47 51 83 11 91, e-mail: [email protected] .

    Application

    To apply for this position please follow the link “Apply for this job”. A short application letter, relevant education and work experience as well as language skills must be registered here.

    The following documents must be uploaded as attachments to your application:

    • a cover letter showing your motivation and interest in the project, and the relevance of your background and experience. 
    • CV with a full summary of your education and experience
    • references, certificates/diplomas and other documentation that you consider relevant
    • Diploma Supplement or similar and a confirmed conversion scale if this is required
    • documentation on competence in English if this is required
    • publications or other relevant research work

    Applications are evaluated based on the information available in Jobbnorge at the application deadline. You should ensure that your application shows clearly how your skills and experience meet the criteria which are set out above and that you have attached the necessary documentation. 

    The documentation must be available in either a Scandinavian language or in English. If the total size of the attachments exceeds 30 MB, they must be compressed before upload.

    Please note that information on applicants may be published even if the applicant has requested not to be included in the official list of applicants – see Section 25 of the Freedom of Information Act . If your request is not granted, you will be notified.

    UiS only considers applications and attachments registered in Jobbnorge.

    General information

    The engagement is to be made in accordance with the regulations in force concerning State Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. If your application is considered to be in conflict with the criteria in the latter legislation, it will be rejected without further assessment.

    Employment as PhD Fellow is regulated in “Regulations concerning terms and conditions of employment for the posts of post-doctoral research fellow and research fellow, research assistant and resident “.

    Your qualifications for the position, based on documentation registered in Jobbnorge, will be assessed by an internal expert committee. Based on the committee’s statement, relevant applicants will be invited to an interview before any recommendations are made. References will also be obtained for relevant candidates. More about the hiring process on our website.

    The appointee will be based at the University of Stavanger, with the exception of a stay abroad at a relevant centre of research.

    It is a prerequisite that you have a residence which enables you to be present at/available to the academic community during ordinary working hours.

    The position has been announced in both Norwegian and English. In the case of differences of meaning between the texts, the English text takes precedence.

    UiS – challenge the well-known and explore the unknown

    The University of Stavanger (UiS) has about 12,000 students and 2,200 employees. The university has high ambitions. We strive to have an innovative and international profile, and be a driving force in knowledge development and in the process of societal change. Our common direction is driven by consideration for green and sustainable change and equitable social development, through new ways of managing natural resources and facilitating better cities and local communities. Energy, health and welfare, learning for life are our focus areas.

    In constant collaboration and dialogue with our surroundings, regionally, nationally and internationally, we enjoy an open and creative climate for education, research, innovation, dissemination and museum activities. Academic life at the University of Stavanger is organised into six faculties comprising various departments/schools and National Research Centres, as well as the Museum of Archaeology. We are a member of the European Consortium of Innovative Universities. The university is located in the most attractive region in the country with more than 300,000 inhabitants. The Stavanger region has a dynamic labour market and exciting cultural and leisure activities.

    Together with our staff and students we will challenge the well-known and explore the unknown.

    The Faculty of Science and Technology offers study programs at bachelor, master and doctoral level. The faculty has established close cooperation on research with NORCE (Norwegian Research Centre AS) and the regional industry. A number of master’s and doctoral theses are made in collaboration with the industry. The faculty has established research collaborations with universities in the US and Europe, and has developed several academic environments that are at the forefront internationally.The faculty has about 2,800 students and approximately 500 employees at the Department of Electrical Engineering and Computer Science, Department of Structural Engineering and Materials Science, Department of Mathematics and Physics, Department of Energy and Petroleum Engineering, Department of Energy Resources and the Department of Safety, Economics and Planning.

    The Department of Chemistry, Bioscience and Environmental Technology offers study programs at all levels within the areas Biological Chemistry, Chemistry and Environment. The department is responsible for basic tuition in chemistry at the faculty. There are currently about 60 employees including doctoral and postdoctoral fellows, and 230 students at the department.

    Requirements

    Research Field
    Medical sciences » Medicine
    Education Level
    Master Degree or equivalent

    Research Field
    Biological sciences » Biology
    Education Level
    Master Degree or equivalent

    Research Field
    Biological sciences » Other
    Education Level
    Master Degree or equivalent

    Research Field
    Engineering » Biomaterial engineering
    Education Level
    Master Degree or equivalent

    Additional Information
    Work Location(s)

    Number of offers available
    1
    Company/Institute
    University of Stavanger
    Country
    Norway
    Geofield

    Where to apply

    Website
    https://www.jobbnorge.no/en/available-jobs/job/247123/phd-fellowship-in-cancer-…

    Contact

    City
    STAVANGER
    Website
    http://www.uis.no
    Street
    Postal Code
    N-4036

    STATUS: EXPIRED

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