PhD candidate ‘Novel therapeutic applications through drug repurposing in thyroid carcinoma (within REPO4EU consortium)’

PhD candidate ‘Novel therapeutic applications through drug repurposing in thyroid carcinoma (within REPO4EU consortium)’
PhD candidate ‘Novel therapeutic applications through drug repurposing in thyroid carcinoma (within REPO4EU consortium)’

Published	Deadline	Location
today	14 Nov	Nijmegen

Job description
We are looking for a PhD candidate with a strong interest in (endocrine) oncology and immuno-oncology for our project ‘Novel therapeutic applications through drug repurposing in thyroid carcinoma” (within REPO4EU consortium)’. The project aims to establish and validate innovative mechanism-based therapeutic strategies as promising and feasible solutions for low-complexity tumors such as thyroid carcinoma. Will you join our ambitious team?
Patients with advanced and undifferentiated thyroid carcinoma have a poor prognosis and limited treatment options. In contrast to other malignant tumors, they are characterized by a low mutational burden and are promising candidates for such an approach through drug discovery and repurposing. The current project includes in vitro, in silico and in vivo proof-of concept studies to validate the feasibility of this concept. The study is part of an exciting collaborative project (REPO4EU) funded by the Horizon Europe program.
Tasks and responsibilities

• Preparation of documentation for Ethics Committee approval.
• Responsible for the planning and logistics of the study.
• Set up of primary cell lines form thyroid cancer tumors and 3D cell cultures.
• DNA and RNA isolation and processing.
• Performing in vitro drug testing and perturbation experiments.
• Performing immunohistochemistry techniques.
• Selecting and recruiting a limited number of patients (10-20) for validation studies and the proof-of-concept clinical trial.
• Aligning procedures and analyses with colleagues from UMC Maastricht.
• Participating and presenting in regular consortium REPO4EU meetings.
• Preparing manuscripts, resulting in a PhD thesis.

Specifications

• 30—38 hours per week
• €2631—€3336 per month
• Nijmegen View on Google Maps

Radboud University Medical Center (Radboudumc)

Requirements
We are looking for a talented, enthusiastic and passionate researcher driven by a high scientific curiosity, is skilled in the lab, dares to think “out of the box” and is a good team player. The PhD candidate should be able and like to cross the bridge from bench to bedside and has the ambition to excel in a multidisciplinary and international scientific environment.
Conditions of employment

Fixed-term contract: 3 years.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

• A gross monthly salary between € 2.631 and € 3.336 (scale 10A) based on full-time employment.
• An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
• If you work irregular hours, you will receive an allowance.
• As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
• Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
• You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.

In addition to our terms of employment , we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the Cao UMC .
Employer
Radboudumc
The PhD candidate will largely work in the Laboratory of Experimental Internal Medicine of the Radboudumc Nijmegen, which is world renowned for its translational research on inflammation/innate immunity and harbors approximately 50 PhD students, 10 postdocs and 10 technicians. The group is highly diverse and has a strong international orientation with researchers working in our Laboratory originating from at least 15 countries, spread across 4 continents.
Within this organization, the Thyroid Carcinoma research group is placed at the forefront of basic, translational and clinical research in thyroid cancer, focusing on understanding the pathogenesis of aggressive forms of thyroid cancer and translational research towards novel therapeutic applications. Within the Radboudumc Center of Excellence for Thyroid Cancer there is a strong cross-fertilisation between patient care and research, between researchers within the group and between the different disciplines involved in thyroid research.
Research Institutes

At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).

• Radboud Institute for Health Sciences: ± 700
• Radboud Institute for Molecular Life Sciences: ± 400
• Donders Center for Medical Neurosciences: ± 200

Read what it is like to do a PhD at the Radboud University Medical Center.
Radboudumc
Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.
Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc
Additional information
Any questions? Please contact Prof.dr. Romana Netea-Maier , internist-endocrinologist. Use the Apply button to submit your application.
#weareradboudumc

Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. We want to have a significant impact on healthcare.

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Application procedure
Any questions? Please contact Prof.dr. Romana Netea-Maier , internist-endocrinologist. Use the Apply button to submit your application.