Multiple Postdoctoral Positions

The Chen laboratory studies how cancer and its immune microenvironment sense and respond to stresses and therapeutic insults to evade immune surveillance and develop drug resistance. We specialize in cancer immunology, ER stress, innate immunity, cancer biology, biochemistry, transgenic and preclinical animal models, and translational research. Publications from the Chen lab include Cell (2024, PMID: 39419025), Science (2023, PMID: 37676964), Nature Cell Biology (2020, PMID: 32958856), Nature Reviews Cancer (2021, PMID: 33214692), JCI (2018, PMID: 29480818), Nature (2014, PMID: 24670641) etc. Our mechanism-driven translational studies have led to first-in-human clinical trial in patients with breast cancer. The highly supportive and interdisciplinary training environment in the Chen lab provides unique career development opportunities for the postdoc trainees. Multiple former postdoc trainees have become Tenure Track Assistant Professors and/or Independent PIs in USA and other country receiving prestigious awards such as CPRIT Scholar Award for First-Time Tenure-Track Faculty Member etc. Our research aims to elucidate the significance and mechanisms of stress responses in therapy resistance and anti-tumor immunity, and develop mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease. Please refer to our representative publications for details: Cell (PMID: 39419025); Science (PMID: 37676964); Nature Cell Biology (PMID: 32958856); Nature Reviews Cancer (PMID: 33214692); JCI (PMID: 29480818); Nature (PMID: 24670641); Cell (PMID: 18555785); Nature Immunology (PMID: 31086333): Nature Cell Biology (PMID: 30778220).  

The Postdoctoral Fellow will conduct experiments, perform data analysis and prepare manuscripts in addition to attending lab meetings, journal clubs, and research seminars. 

Requirements: 

Individuals with a PhD degree in immunology, biochemistry, molecular biology, genetics,, cancer biology, or related fields, with a strong sense of curiosity and passion for science are required. Strong background and working knowledge in immunology, biochemistry, molecular biology and cancer biology is preferred. Expertise in flow cytometry, biochemistry and animal models is strongly preferred.  

Contact: Dr. Xi Chen, email: xchen23@mdanderson.org 

Application Deadline: 

Consideration of applications will begin immediately and continue until the position is filled.  

*Stipend: 

Stipend support will follow the NIH Kirschstein-NRSA stipend levels level for the appropriate PGY. 

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. 

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