Molecular Mechanisms of Receptor and Ion Channel Regulation in Pain and Inflammation
University of Reading
About the Project
Are you ready to delve into the captivating world of molecular signaling and unravel the mysteries of the cardiovascular and nervous systems? We are thrilled to offer an exhilarating PhD opportunity at the forefront of scientific exploration.
About the Project: Receptors and ion channels serve as the gatekeepers of cellular communication, orchestrating the plethora of signals that regulate diverse biological functions. At the heart of our research lies the intricate molecular mechanisms governing these crucial components. From G protein-coupled receptors to toll-like receptors and ion channels, we examine the mechanisms that shape signal transduction pathways to regulate biological functions. Our projects aim to understanding the complexities of protein-protein interactions, trafficking dynamics, and biased agonism, and their pivotal roles in pain transmission and inflammatory processes.
Cutting-Edge Research: Immerse yourself in a dynamic research environment where innovation thrives. Collaborate with leading experts in molecular biology, biochemistry, pharmacology, and genetics, harnessing state-of-the-art tools and techniques to unravel the secrets of cellular signaling.
Specialist Training: Dive into a comprehensive training program tailored to equip you with expertise in molecular, biochemical, pharmacological, and microscopic methodologies. From cell culture and immunohistochemistry to gene editing and signaling assays, we empower you to push the boundaries of scientific discovery.
Impactful Research: Make a tangible difference in the fight against pain and inflammatory disorders. Gain insights into new therapeutic targets with the potential to transform treatments for conditions like migraine, asthma, and inflammatory bowel disease, improving the lives of millions worldwide.
Join Our Team: Are you driven by curiosity and a passion for unraveling the complexities of molecular signaling? If so, we invite you to be part of our vibrant research groups, where every experiment brings us closer to unlocking the secrets of life itself.
Apply Now: Seize this extraordinary opportunity to embark on a journey of scientific discovery and personal growth. Submit your application today and become a catalyst for change in the field of molecular research.
• Methods include:
o Cell culture of cell lines
o Plasmid transfections, viral transductions
o Immunocytochemistry/immunohistochemistry
o Western blotting
o Confocal laser scanning microscopy
o FRET/BRET-based signaling assays
o Ca2+-signaling assays
o Plasmid DNA cloning, RT-PCR, qPCR
o Gene editing e.g., CRISPR/Cas9
o Cell-based assays e.g. viability and proliferation assays
o Gene reporter assays e.g., Luciferase assays
Key words: GPCRs, Ion channels, Signaling, Trafficking, Pain, Inflammation.
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