Mechanisms of control of 3D genome organisation

We have an exciting opportunity for exceptional PhD students to join us in a world-class research environment. We can offer a funded 3.5-year PhD scholarship open to UK and Overseas applicants.

The major aim of this PhD project is to unlock a key mystery in genome regulation. The project is part of an interdisciplinary, collaborative and international project involving groups in Imperial College London, the Netherlands Cancer Institute (NKI) Amsterdam, the University of Oxford, and the University of Leicester. This project focuses on understanding molecular mechanisms that control the regulation of 3D genome organisation. The 3D genome organization refers to the spatial arrangement of chromatin within the nucleus, including the positioning of chromosomes, formation of chromatin loops, and interactions between regulatory elements such as promoters and enhancers. 

The dysregulation of 3D genome organization has been increasingly recognized as a significant factor in cancer development and progression. We aim to understand the molecular mechanisms that enable control of 3D genome organization. Understanding these control mechanisms will be essential for identifying novel therapeutic strategies.

We offer

• Collaborative and supportive research environment
• State-of-the-art laboratory facilities
• Mentorship from experienced researchers and professors
• Access to a vibrant scientific community
• Opportunities for national and international collaborations

Your role

As a PhD candidate, you will play a pivotal role in conducting experiments, analysing data, and interpreting results. You will engage in interdisciplinary research that combines structural biology, molecular biology, genomics, and bioinformatics to gain a holistic understanding of molecular mechanisms that enable control of 3D genome organization. You will contribute to publications, attend conferences, and develop a skill set that will propel your career in academia or industry.

• Enquiries to the project supervisor Professor Daniel Panne (daniel.panne@le.ac.uk)

TO APPLY please refer to our web page https://le.ac.uk/study/research-degrees/funded-opportunities/mcb-panne