University of Virginia
The Tang Laboratory at the Department of Biochemistry and Molecular Genetics (BMG) at the University of Virginia School of Medicine seeks applicants for a new Lab Specialist.
The Tang laboratory studies mechanisms of complex genome rearrangements in cancers and other human diseases such as developmental disorders, particularly interested in chromothripsis which is a catastrophic rearrangement involving ten to hundreds of DNA breaks randomly ligated all at once within one or few chromosomes. We are interested in understanding how these breaks are formed and how they are repaired in different cellular contexts. We are also interested in abnormal gene regulation, such as oncogene activation and defects in RNA processing, in contribution to genome instability. One of our focuses is to delineate the mechanism of how dysregulation of R-loops, three-stranded nuclear acid complexes comprised of a DNA-RNA hybrid and a displaced single-stranded DNA, leads to DNA damage and genome instability in somatic and meiotic cells. The overall goal of our research is to identify mechanisms of complex genome rearrangements that drive rapid genome evolution in cancers and congenital human disorders.
Our lab uses a wide range of techniques to study genome instability and rearrangements. The technician will work directly with the Principal Investigator of the lab and will be provided comprehensive academic training. The research technician is highly encouraged to lead and develop their own independent research projects.
JOB RESPONSIBILITIES include:
Assist the Principal Investigator and other lab members, such as graduate students, and postdoc researchers in their research projects. Experimental work includes mammalian cell culture and live cell/fixed cell microscopic imaging combined with single cell genomic analysis (Look-seq) and in vitro biochemistry analysis with purified proteins.
Participate and present research progress in regular lab meetings. Attend departmental seminars and national scientific conferences.
Order general lab supplies and help with the overall laboratory maintenance, including maintaining a clean workspace and preparing buffers and other reagents.
Bachelor’s degree in a related field and at least 3 years of previous experience. 6 years of related lab experience may be considered in lieu of a degree.
Basic cell biology and molecular biology skills are required. Experience with microscopy, cell culture and protein purification would be beneficial.
Ability to draft routine reports and keep accurate and detailed records of work performed.
This is a restricted position and is dependent upon project need, availability of funding and performance. Salary will be commensurate with education, skills, and experience. For more information on the benefits at UVA, visit https://hr.virginia.edu/benefits .
The selected applicant will be required to complete a background check prior and health assessment per University policy.
TO APPLY :
Please visit UVA job board: https://uva.wd1.myworkdayjobs.com/UVAJobs and search for “R0053667”
Complete an application online and attach:
Cover letter to include your interest in the position and your knowledge, skills, abilities, and experiences
Resume or CV
PROCESS FOR INTERNAL UVA APPLICANTS: Please apply through your Workday Home page, search “Find Jobs”, and search for “R0053667″.
***Please note that you MUST upload ALL documents into the CV/Resume box. Applications that do not contain all of the required documents will not receive full consideration. ***
For questions about the application process, please contact Rhiannon O’Coin, Senior Academic Recruiter, [email protected]
For more information about UVA and the Charlottesville community please see www.virginia.edu/life/charlottesville and https://embarkcva.com/
This position can spend extensive periods of time standing and squatting while conducting experiments. Also requires keyboarding and other bench work requiring finer finger manipulation.
The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person’s perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.
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