How does early life influence the brain and behavioural profile of a mouse model for schizophrenia
Cardiff University
About the Project
Rare variants in the gene SETD1A are consistently linked to the incidence of schizophrenia. Using a mouse model in which Setd1a is deleted (“knocked-out”, Setd1a-ko) we, and others, have identified deficits in behaviour and brain activity related to information processing. In addition, our work has demonstrated that the adult brain and behavioural profile of Setd1a-ko mice may, in part, be due to changes that occur very early in life. This project aims to explore how the brain and behavioural profile of Setd1a-ko mice develops.
Specifically, the primary objective are:
• Define the cognitive profile of Setd1a-ko mice using sophisticated behavioural neuroscience methods
• Examine how Setd1a-ko mouse behaviour develops in early life using home-cage monitoring
• Use a conditional model to dissociate indirect effects of Setd1a deletion on brain and behavioural development
Please contact Professor Anthony Isles, [email protected] for more information about this project.
Application forms and further information about applying to the Hodge PhD Scholarship Programme can be obtained from [email protected].
Competed application forms must be sent to [email protected]
Only one form will be considered per applicant. You can select up to 2 projects funded by the Hodge PhD Scholarship Programme in one application form.
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Provisional Interview Date – Tuesday 25th June 2024
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