DNA Encoded Libraries to Identify New Cancer Targets.

Project Overview

DNA encoded libraries (DELs) have become an established technology to generate hits for various drug discovery programs. The technology combines the power of combinatorial chemistry, PCR, and Next Generation Sequencing (NGS) to screen millions of barcoded compounds against targets of interest. This research project will take DNA encoded libraries to the next level in drug discovery. The project will bridge two key stages in drug discovery to identify targets and ligands synergistically in unmet cancer therapeutic needs.

Project Objectives

DNA encoded libraries have a huge potential to screen millions of compounds in one-go against immobilised purified targets. Design of focused libraries based on privileged building blocks will allow the encoded chemical spaces to act as warheads to identify new targets and their ligands synergistically. The project aims to: (i) design focused libraries for screening against specific targets, (ii) include identified hits in the design of bifunctional DNA encoded libraries, (iii) screen against mixtures of targets in their biological environment.

The project will provide in-depth training in the fast-growing field of DNA encoded libraries along with (theoretical and practical) training in drug design, organic and medicinal chemistry, and chemical biology, which are essential for an interdisciplinary future career in drug discovery.

You will work with experienced team in the Department of Chemistry, School of Life Sciences and Sussex Drug Discovery Centre (SDDC). You will be monitored closely and work in an industry-level environment and will be exposed to different techniques and research projects. 

Subject Areas:

DNA encoded libraries, Drug discovery, Medicinal Chemistry, Chemical Biology. 

How to apply:

Please submit a formal application through the online admissions portal attaching a CV, degree transcripts and certificates, personal statement, and two academic references. A research proposal is not required.

On the application system select Programme of Study – PhD chemistry. Please ensure you state the project title under funding obtained and include the supervisor’s name where required.

Applications are particularly welcomed from candidates with protected characteristics – e.g., from Black and other ethnic minorities – who are under-represented in postgraduate research at our institution.

Ideal candidates will have a background in chemical biology, biochemistry and organic chemistry or in a related subject such as Life Sciences or a pharmacy degree. They should have strong interest in interdisciplinary work in a Life-Science-related subject. Candidates should have or expect to obtain a minimum 2:1 undergraduate degree. An MSc degree will be advantageous. Your qualification should be in chemistry, or biochemistry, or a related subject area. You may also be considered for the position if you have other professional qualifications or experience of equivalent standing.

For enquiries about the project, please contact supervisor Dr Haitham Hassan: haitham.hassan@sussex.ac.uk