Develop a Novel Non-Invasive Test for Early Detection of Preeclampsia

Aim: To identify novel biomarkers from maternal blood plasma for the prediction and better management of preeclampsia during pregnancy.

We are seeking a motivated PhD candidate to develop a novel multimodal non-invasive test for early detection of preeclampsia, a major pregnancy complication affecting millions worldwide. This project combines proteomics and circulating cell-free DNA (cfDNA) profiling to identify new biomarkers, improving early diagnosis of late-onset preeclampsia. You will integrate biomarker discovery with existing clinical data using patient samples. HTA training would be mandatory. This project will suit candidates with hands-on experience in molecular biology techniques (DNA extraction, PCR, NGS library preparation) and strong analytical and problem-solving skills. Attention to detail and good organisation skills are mandatory. Experience in omics and NGS data analysis using bioinformatic pipelines would be an advantage. This is a combination of wet lab and dry lab projects with the potential of developing a model for better prediction and classification of pregnancies at risk. This research offers a unique opportunity to contribute to cutting-edge advancements in women’s health by developing a non-invasive assay for early detection using biomarkers found in maternal circulation. By joining this project, you can be pivotal in transforming fetal medicine, improving pregnancy outcomes, and addressing a critical global healthcare challenge.

These PhD opportunities will include comprehensive personal and professional development training and a mentoring programme from the University of Westminster Graduate School. The researchers will join a School firmly committed to decolonising and diversifying policies, practices, and cultures within, and beyond, Higher Education. 

Entry requirements and how to apply

Candidates should have a minimum classification of 2.1 in their bachelor’s degree or equivalent and preferably a Masters degree. Applicants whose secondary level education has not been conducted in the medium of English should also demonstrate evidence of appropriate English language proficiency normally defined as IELTS: 6.5 (overall score with not less than 6.0 in any of the individual elements).

You can read more about what should be in a PhD research proposal here:

https://www.westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements/how-to-write-your-research-proposal

You can read more about our entry requirements here:

http://westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements

Applications should be submitted by Friday 16^th May 2025. Interviews will take place in June.

It is essential you include the code of the project you are applying for in your personal statement i.e. “SLS SF1”.

Also include the title of the specific project you wish to apply for in your application.