Chemical modification of mRNA for enhanced translation

mRNA vaccines have emerged as a new modality for preventing infectious diseases and treating cancer. This is due to their ability to rapidly produce specific proteins inside cells in a programmable manner. However, there remains a need for further development and optimisation of this novel technology. Increasing the rate of translation to protein in vivo will either enhance the pharmacological effect of mRNA or allow the same effect to be obtained using a lower dosage. One strategy to achieve this is the use of chemical modifications of mRNA, which can alter its interactions with ribosomes and other regulatory proteins.

This interdisciplinary project will involve the synthesis of novel nucleotide derivatives, incorporation of these modified nucleotides into RNA strands, and biological testing to assess the effect on translation. Candidates should have a strong background in synthetic organic chemistry, and an interest in applying this experience to biological problems. Training will be provided in RNA synthesis, biochemical assays, and analytical methods for investigating RNA. The successful candidate will gain cutting edge skills spanning both chemistry and biology and will be well positioned to pursue a career in an exciting new field.

Funding for this project is for 3 years and applicants should contact cceresearch@qub.ac.uk for any queries related to the project. 

Applications will only be considered if they are submitted via the QUB Direct Application portal https://myportal.qub.ac.uk/SignIn?ReturnUrl=%2Fpg-admission-application-list%2F