Institute of Ophthalmology 3-Year PhD Studentship
UCL Department / Division: UCL Institute of Ophthalmology, Faculty of Brain Sciences
Duration of Studentship: Full-time over 3 years, available to start from 1 October 2025
PhD Title: Cell Biology of Ageing in AMD
Supervisor(s): Professors Maria Balda and Karl Matter
We are offering a full–time, 3-year PhD studentship to research molecular mechanisms contributing to retinal degeneration and to test for novel therapies.
The goal of the project is to test a novel therapy in a new mouse model of retinal degeneration. This research will analyse a new pathway in a retinal degeneration mouse model induced by knockout p114RhoGEF in specific retinal cells to understand the disease of patients with biallelic mutations in this gene. In this context, we will also test a potential novel therapeutic tool that could be further developed for treatments to restore vision in patients. The outcomes will increase the understanding of the molecular mechanisms underlying retinal degeneration and test a new treatment for retinal diseases.
Applicants should hold or expect to receive a minimum upper–second degree or equivalent in a life science discipline. A Master’s degree or previous lab–based research experience is desirable.
Part of the Faculty of Brain Sciences, the UCL Institute of Ophthalmology is ranked the best place in the world to study ophthalmology (CWUR Rankings by Subject 2017). Our partnership with Moorfields Eye Hospital represents the largest co–located site for eye research, education and care in the world.
Duties and Responsibilities
The successful candidate is expected to:
Person Specification
Commencement
The successful candidate is expected to start on 1 October 2025.
Funding Notes
This full-time studentship is funded for three years by Moorfields Eye Charity and is inclusive of UK home rate tuition fees, laboratory costs and an annual salary stipend starting at £22,000. International students: please see the details in the ‘Eligibility’ item below.
Eligibility
The full studentship (tuition fees and salary stipend) is eligible for candidates classified as UK students (please see ‘Tuition fee classification’ on this page: https://www.ucl.ac.uk/prospective-students/graduate/tuition-fees). Applicants that incur overseas fees are welcome to apply and would be expected to cover the difference in UK home and overseas rates of tuition (see here for more details: https://www.ucl.ac.uk/students/fees-and-funding/pay-your-fees/fee-schedules/2024-2025/postgraduate-research-fees-2024-2025).
Enquiries
Enquiries relating to the application process should be sent to the Research Degrees Manager at ioo.pgr@ucl.ac.uk.
How to apply
Please prepare a single PDF document in the following order:
Attach to an email with the reference MBMCH25 in the subject line and send to the Research Degrees Manager at ioo.pgr@ucl.ac.uk by the deadline stated below. We ask that applicants follow these instructions carefully since deviation from them may invalidate your application. Any details specified in the body of email messages will not form part of the application.
Application deadline: 23:59 British Summer Time (BST), Friday 30 May 2025.
Proposed interview date: Week beginning 16 June 2025. Shortlisted candidates will be contacted directly with further details of interview times.
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