Biology of Ageing and Rejuvenation

We are seeking talented, motivated students with a passion for research in the biology of ageing to join the Genomics of Ageing and Rejuvenation Lab led by Prof Joao Pedro de Magalhaes (https://rejuvenomicslab.com/). Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

The goal of our lab is to develop innovative research on the biology of ageing, in particular in the context of large-scale -omics approaches. We use different methods combining experimental, theoretical, and computational approaches. Experimentally, we have extensive experience in mammalian cell biology and molecular techniques. We have worked with various animal models, though we are not restricted to one model system and students may develop their own independent research projects. A multidisciplinary outlook and collaborations are encouraged.

We are located in the Institute of Inflammation and Ageing, part of the College of Medical and Dental Sciences, at the University of Birmingham. Situated in the largest healthcare region in the country, we have state-of-the-art facilities and equipment to support our research needs, including in cell and molecular biology, genomics, epigenetics and bioinformatics.

Potential applicants are encouraged to contact Prof de Magalhaes in the first instance for an informal discussion – https://rejuvenomicslab.com/contact/ ADDITIONAL INFORMATION For additional information on the Genomics of Ageing and Rejuvenation Lab please click – https://rejuvenomicslab.com/ For additional information on Prof de Magalhaes please click – https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/magalhaes-pedro.aspx

Funding notes:

Applicants are invited from self-funded or scholarship-funded graduates only. Applicants will be self-funded or will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations. Overseas graduates require IELTs of 6.5 overall.

References:

de Magalhães JP (2024) “Distinguishing between driver and passenger mechanisms of aging.” Nature Genetics 56:204-211.

de Magalhães JP (2024) “Cellular senescence in normal physiology.” Science 384:1300-1301.

Bennett DF, Goyala A, Statzer C, Beckett CW, Tyshkovskiy A, Gladyshev VN, Ewald CY, de Magalhães JP (2023) “Rilmenidine mimics caloric restriction via the nischarin I1-imidazoline receptor to extend lifespan in C. elegans.” Aging Cell 22:e13774.

Chatsirisupachai K et al. (2021) “An integrative analysis of the age-associated multi-omic landscape across cancers.” Nature Communications 12:2345.

Avelar RA et al. (2020) “A multidimensional systems biology analysis of cellular senescence in ageing and disease.” Genome Biology 21:91.